HANABI Metaphase Chromosome Harvesters

The HANABI Metaphase Chromosome Harvesters are the first systems to fully automate the multi-step process of preparing and harvesting metaphase cells derived from blood and bone marrow cell cultures and from other cell suspension cultures for cytogenetic analyses. Centrifugation, aspiration, addition of hypotonic and fixative solutions, and cell resuspension are all automated. Walk away reliability and low maintenance significantly reduce FTE time associated with the manual harvesting process.

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Product Description

The HANABI Metaphase Chromosome Harvesters are the first systems to fully automate the multi-step process of preparing and harvesting metaphase cells derived from blood and bone marrow cell cultures and from other cell suspension cultures for cytogenetic analyses. Centrifugation, aspiration, addition of hypotonic and fixative solutions, and cell resuspension are all automated. Walk away reliability and low maintenance significantly reduce FTE time associated with the manual harvesting process.

The HANABI Metaphase Chromosome Harvesters are the first systems to fully automate the multi-step process of preparing and harvesting metaphase cells derived from blood and bone marrow cell cultures and from other cell suspension cultures for cytogenetic analyzes. Centrifugation, aspiration, addition of hypotonic and fixative solutions, and cell resuspension are all automated. Walk away reliability and low maintenance significantly reduce FTE time associated with the manual harvesting process.

ADS BIOTEC offers three harvester platforms to meet the requirements of small to large sample throughput laboratories.

HANABI PIsample throughput from 1 to 16 tubes
HANABI PII Plussample throughput from 1 to 24 tubes
HANABI PIII Plussample throughput from 1 to 64 tubes

    
      

Features

  • Sample volume flexibility (16 tubes, 24 tubes, 64 tubes)
  • Easy-program/Easy-view digital touch control screen
  • Protocol customization
  • Fully automated and walk away from centrifugation through final fix 
  • Cell pellets are ready for dropping using HANABI PIV Metaphase Auto-Spreader after final fix

Benefits

  • Provides exceptionally consistency
  • Frees up laboratory hands-on time increasing productivity and throughput
  • Simple and user-friendly programmability
  • Optimization of protocols and results for specific cell types including blood, bone marrow and other suspension cultures
  • Select your program, press START and walk away
  • Delivers cells with less debris for cleaner spreads and high mitotic index
  • FISH, G-Banding, cytological or immunocytochemical analysis

Samples

Courtesy of Brigham and Women’s Hospital, Department of Cytogenetics, Boston, MA

 

FISH Analysis of Chromosomes and Interphase Cells Obtained with the HANABI-PII Metaphase Chromosome Harvester

Courtesy of Michele Wiggins, Human Genetics Laboratories, University of Nebraska Medical Center

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Introducing the HANABI Harvesters

FeaturePIPIIPII PlusPIII Plus
Number of Samples16242464
Number of Programmable Protocols6366
Average Harvesting Time Per Run (Dependent on Lab Protocol)Approximately 1.5 hoursApproximately 2.0 hoursApproximately 2.0 hoursApproximately 2.5 hours
Centrifuge1 to 10 minutes at 1,500 rpm - Approximately 370 g force1 to 10 minutes at 1,000 rpm - Approximately 230 g force1 to 10 minutes at 1,200 rpm - Approximately 320 g force1 to 10 minutes at 1,000 rpm - Approximately 310 g force
Centrifuge tube size:15 mL tube, up to 10 mL volume15 mL tube, up to 10 mL volume15 mL tube, up to 10 mL volume15 mL tube, up to 10 mL volume
Centrifuge tube options:Falcon StandardFalcon StandardFalcon StandardFalcon Standard
Centrifuge chamber temperature:Programmable temperature - ambient to 40ºCProgrammable temperature - ambient to 40ºCProgrammable temperature - ambient to 40ºCProgrammable temperature - ambient to 40ºC
External Size (W x H x D)/Weight850 (mm/W) x 1,600 (mm/H) x 700 (mm/D), Approximately 250 kg990 (mm/W) x 1855 (mm/H) x 710 (mm/D), Approximately 370 kg850 (mm/W) x 1,600 (mm/H) x 750 (mm/D), Approximately 300 kg( US model ) 1005 (mm/W) x1800 (mm/H) x730 (mm/D) Approximately 430 kg
( EC model ) 1005(mm/W) x2200(mm/H) x730 (mm/D) Approximately 460 kg
SPI - auto-fixative mixer:Accessory available for auto-mxing of fixative solutionAccessory available for auto-mxing of fixative solutionAccessory available for auto-mxing of fixative solutionAccessory available for auto-mxing of fixative solution
Reagents EnvironmentHypotonic solution: 15-30ºC, can be warmed to 37ºC, fixative solution: chilled (on ice) to ambient temperatureHypotonic solution: 15-30ºC, can be warmed to 37ºC, fixative chilled on ice to ambient temperatureHypotonic solution: 15-30ºC, can be warmed to 37ºC, fixative chilled on ice to ambient temperatureHypotonic solution: 15-30ºC, can be warmed to 37ºC, fixative chilled on ice to ambient temperature
Operating Environment:15 - 30ºC, 20-60% RH15 - 30ºC, 20-60% RH15 - 30ºC, 20-60% RH15 - 30ºC, 20-60% RH
Power100, 120, 230 VAC; 50 or 60 Hz 100, 120 VAC; 50 or 60 Hz 100, 120, 230 VAC; 50 or 60 Hz 100, 120, 230 VAC; 50 or 60 Hz

Support Plan

Click Hanabi Metaphase Chromosome Harvester Support Plan for the pdf version of the support plan.

ADS BIOTEC realizes the importance of maintaining your laboratory’s smooth and efficient operation. The HANABI Metaphase Chromosome Harvester requires appropriate care and maintenance for optimal performance. Planning post-warranty maintenance is a critical part of laboratory management. Through the HANABI Metaphase Chromosome Harvester Support Plan, we take care of all your post-warranty service needs. This plan includes an annual preventative maintenance program and emergency service support to minimize unscheduled downtime for repairs.

The HANABI Metaphase Chromosome Harvester Support Plan includes the following benefits:

  • One annual preventative maintenance visit at no additional charge.
  • Emergency service visits as required to address operational failures.
  • Replacement parts provided at no charge (excludes consumables and routine replacement parts
  • such as lamps, bottles, filters, PTFE tubing and couplers).
  • Travel and labor expenses associated with preventative maintenance and emergency visits are included.
  • Telephone Hotline Support.

Warranty

Click here for the pdf version of the warranty.

The HANABI Metaphase Chromosome Harvesters are warranted to be free from defects in material and workmanship for twelve months following installation, or fourteen months following shipment, whichever occurs first.

The HANABI Metaphase Chromosome Harvester Warranty includes the following benefits:

  • One annual preventative maintenance visit at no additional charge.
  • Emergency service visits as required to address operational failures.
  • Replacement parts provided at no charge (excludes consumables and routine replacement parts such as lamps, bottles, filters, PTFE tubing and couplers).
  • Travel and labor expenses associated with preventative maintenance and emergency visits are included.
  • Telephone Hotline Support.

Excluded are no charge replacement parts, travel and labor costs if there is fault or negligence by the customer through misuse or accident. Also excluded are chemistry, consumables and applications issues.

Warranty Terms

Products are supplied for research use only. ADS BIOTEC warrants the Products are free from defects in material and manufacture and conform to ADS BIOTEC’s specifications at the time of shipment. Subject to verification by ADS BIOTEC, if any Product fails to conform to the specifications or any defect in material or manufacture appears: 1) for Products which are scientific instruments within one (1) year from the date of installation; and 2) for related Consumable Products, modules and parts within 30 days from the date of shipment, ADS BIOTEC’s entire liability and Customer’s exclusive remedy shall be, at ADS BIOTEC’s sole discretion, the repair or replacement of the defective Products.

Limitations to Warranty

Unless a separate service plan is purchased, all regularly scheduled maintenance and repairs during the Warranty term shall be the responsibility of Customer. This warranty does not cover any damage to Products due to misuse, improper site selection, and maintenance or operation by Customer or any others which is contrary to recommended instructions and design parameters for the Products. This warranty does not cover damage or defects resulting from repair or relocation of the Products by anyone other than a ADS BIOTEC representative. After the initial installation of the Products any post installation realignment, readjustment, recleaning, or recalibration, unless due to defects in material or workmanship, are the responsibility of Customer. Certain items which are refurbished or otherwise reconditioned are also excluded from the terms of this warranty. This warranty does not cover any damage due to accidents, vandalism, fire, flood, other environmental factors or any other Force Majeure. If you have questions regarding warranty coverage, please contact ADS BIOTEC Customer Service.

The warranty further excludes items supplied by third party manufacturers, such as computers and related software. Customer is responsible for any modifications to the computers or software including, but not limited to: interfacing or networking; unauthorized hardware modifications; repartitioning or reformatting of the hard drive; installation or modification of additional or new hardware; and installation or reinstallation of new or existing computer operating systems or service packs.

THIS WARRANTY IS MADE IN LIEU OF ALL OTHER WARRANTIES, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE; ANY IMPLIED WARRANTY ARISING OUT OF A COURSE OF DEALING OR OF PERFORMANCE, CUSTOM OR USAGE OF TRADE; OR ANY IMPLIED WARRANTY AGAINST PATENT INFRINGEMENT. UNDER NO CIRCUMSTANCES SHALL ADS BIOTEC BE LIABLE FOR DAMAGES OF ANY KIND, INCLUDING WITHOUT LIMITATION, DIRECT, INDIRECT, INCIDENTAL, SPECIAL OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, LOSS OF PROFITS, REVENUE OR BUSINESS) RESULTING FROM OR IN ANY WAY RELATED TO THE PRODUCTS. These limitations apply regardless of whether such damages are sought based on breach of contract, negligence, strict liability in tort, or any other legal theory. The liability of ADS BIOTEC relating to any order by Customer shall in no event exceed the total amount of the payments received by ADS BIOTEC relating to such order. Without regard to any applicable statute of limitations, Customer agrees that any legal action related to any order must be commenced within ninety (90) days of the purchase date.

By placing their order, Customers represent and warrant that they and their employees and agents shall comply with all applicable laws, ordinances, regulations and codes in handling, storage and use of Products and shall indemnify and hold harmless ADS BIOTEC from any claims, rights or causes of action related thereto, or to Customer’s failure act in accord with
these terms and warranties.

To the best of its information and belief, ADS BIOTEC has the necessary intellectual property rights to make the Products. Please contact the ADS BIOTEC Law Department at 7409 Irvington Road, Omaha, NE 68122 with any specific questions. While information and data presented are accurate and reliable to the best of ADS BIOTEC’s information and belief, ADS BIOTEC does not guarantee the accuracy of any information and data, nor do we represent that reliance upon such information and data

Catalog NumberNameDescription
HCMH-99-0001-AHANABI-PII PLUS Metaphase Chromosome HarvesterFully automated system for the collection and preparation of metaphase cells from culture to final fixation. Cells prepared from 1 to 24 culture tubes can be used directly for chromosome and karyotype analysis.
HCMH-99-0003-AHANABI-PIII Metaphase Chromosome HarvesterFully automated system for the collection and preparation of metaphase cells from culture to final fixation. Cells prepared from 1 to 64 culture tubes can be used directly for chromosome and karyotype analysis.
HCMH-99-00P1-AHANABI-PI Metaphase Chromosome HarvesterFully automated system for the collection and preparation of metaphase cells from culture to final fixation. Cells prepared from 1 to 16 culture tubes can be used directly for chromosome and karyotype analysis.
SER-HARVHANABI-PII Metaphase Harvester Support PlanOne year instrument service support plan including one preventative maintenance visit.
SER-HARV PIIIHANABI-PIII Metaphase Harvester Support PlanOne year instrument service support plan including one preventative maintenance visit.
SER-HARV-PIHANABI-PI Metaphase Harvester Support PlanOne year instrument service support plan including one preventative maintenance visit.

Hanabi Harvesters Flyer- US Outline
Hanabi Harvesters Flyer- EU Outline

Application Note 129 HANABI-PIIPlus Harvester Operation for Peripheral Blood and Bone Marrow
HANABI PIII-poster ACC conference 2009